Folding@Home for COVID-19

I setup Folding@Home and started contributing computing resources to Covid-19 project.

For Covid-19, the Folding@Home project is trying to find out the structure of covid-19 virus as it comes in contact with human bodies through ACE2 receptor Angiotensin-converting enzyme 2 (ACE2) is an enzyme that can be found either attached to the membrane of cells (mACE2) in the intestines, kidney, testis, gallbladder, and heart or in a soluble form (sACE2). Both membrane bound and soluble ACE2 are integral parts of the renin–angiotensin–aldosterone system (RAAS) that exists to keep the body's blood pressure in check. mACE2 is cleaved by the enzyme ADAM17 in a process regulated by substrate presentation. ADAM17 cleavage releases the extracellular domain creating soluble ACE2 (sACE2). ACE2 enzyme activity opposes the classical arm of the RAAS by lowering blood pressure through catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide which raises blood pressure) into angiotensin (1–7) (a vasodilator). Angiotensin (1-7) in turns binds to MasR receptors creating localized vasodilation and hence decreasing blood pressure. This decrease in blood pressure makes the entire process a promising drug target for treating cardiovascular diseases. , and how an understanding of this can help build therapeutic antibiotics or molecules that might disrupt the viral interaction.

Stats: https://stats.foldingathome.org/donor/Senthil.Kumaran

Folding@Home hit a milestone Exaflop Exascale computing refers to computing systems capable of calculating at least 1018 IEEE 754 Double Precision (64-bit) operations (multiplications and/or additions) per second (exaFLOPS)"; it is a measure of supercomputer performance. computing speed, which is a billion billion floating point operations per second.

Let's not leave any stone unturned.